Protein Phosphatase 2C
Synonyms
2C, Protein Phosphatase
Magnesium Dependent Protein Phosphatase 2C beta
Magnesium-Dependent Protein Phosphatase 2C beta
PP2C beta
PP2Cepsilon
PP2Cgamma
PPM1 Magnesium Dependent Protein Phosphatases
PPM1 Magnesium-Dependent Protein Phosphatases
PPM1 Protein Phosphatases
PPM1D Phosphatase
PPM1E Phosphatase
PPM1G Phosphatase
Phosphatase 2C, Protein
Phosphatase, PPM1D
Phosphatase, PPM1E
Phosphatase, PPM1G
Phosphatase, Ppm1b
Phosphatase, Ptc2
Phosphatases, PPM1 Protein
Ppm1b Phosphatase
Protein Phosphatase 1D Magnesium Dependent, delta isoform
Protein Phosphatase 1D Magnesium-Dependent, delta isoform
Protein Phosphatase 2C beta
Protein Phosphatase 2C delta
Protein Phosphatase 2C epsilon
Protein Phosphatase 2C gamma
Protein Phosphatases, PPM1
Ptc2 Phosphatase
beta, PP2C
One of four major classes of mammalian serine/threonine specific protein phosphatases. Protein phosphatase 2C is a monomeric enzyme about 42 kDa in size. It shows broad substrate specificity dependent on divalent cations (mainly manganese and magnesium). Three isozymes are known in mammals: PP2C -alpha, -beta and -gamma. In yeast, there are four PP2C homologues: phosphatase PTC1 that have weak tyrosine phosphatase activity, phosphatase PTC2, phosphatase PTC3, and PTC4. Isozymes of PP2C also occur in Arabidopsis thaliana where the kinase-associated protein phosphatase (KAPP) containing a C-terminal PP2C domain, dephosphorylates Ser/Thr receptor-like kinase RLK5.