Sterol 14-Demethylase
Synonyms
14 alpha-Demethylase, Eburicol
14 alpha-Demethylase, Lanosterol
14-Demethylase, Sterol
14-Demethylases, Sterol
14-alpha-Demethylase, Sterol
14alpha-Demethylase, Eburicol
14alpha-Demethylase, Obtusifoliol
CYP51 Cytochrome P 450
CYP51 Cytochrome P-450
CYP51, Cytochrome P-450
Cytochrome P 450 CYP51
Cytochrome P-450 CYP51
Cytochrome P-450, CYP51
Eburicol 14 alpha Demethylase
Eburicol 14 alpha-Demethylase
Eburicol 14alpha Demethylase
Eburicol 14alpha-Demethylase
Lanosterol 14 alpha Demethylase
Lanosterol 14 alpha-Demethylase
Obtusifoliol 14alpha Demethylase
Obtusifoliol 14alpha-Demethylase
P-450 CYP51, Cytochrome
P-450, CYP51 Cytochrome
Sterol 14 Demethylase
Sterol 14 Demethylases
Sterol 14 alpha Demethylase
Sterol 14-Demethylases
Sterol 14-alpha-Demethylase
An NADPH-dependent P450 enzyme that plays an essential role in the sterol biosynthetic pathway by catalyzing the demethylation of 14-methyl sterols such as lanosterol. The enzyme acts via the repeated hydroxylation of the 14-methyl group, resulting in its stepwise conversion into an alcohol, an aldehyde and then a carboxylate, which is removed as formic acid. Sterol 14-demethylase is an unusual cytochrome P450 enzyme in that it is found in a broad variety of organisms including ANIMALS; PLANTS; FUNGI; and protozoa.