Suppressor of Cytokine Signaling Proteins

Synonyms

SOCS Proteins

Suppressors of Cytokine Signaling Proteins

A family of structurally related proteins that are induced by CYTOKINES and negatively regulate cytokine-mediated SIGNAL TRANSDUCTION PATHWAYS. SOCS proteins contain a central SH2 DOMAIN and a C-terminal region of homology known as the SOCS box.