Tartrate-Resistant Acid Phosphatase
Synonyms
AcPase V
Acid Phosphatase V
Acid Phosphatase, Tartrate-Resistant
Phosphatase V, Acid
Phosphatase, Tartrate-Resistant Acid
TRAP Type 5 AcPase
TRAcP
Tartrate Resistant Acid Phosphatase
Tartrate Resistant Acid Phosphatase Type 5
Tartrate-Resistant Acid Phosphatase Type 5
Type 5 Acid Phosphatase
Uteroferrin
V, AcPase
V, Acid Phosphatase
One of several acid phosphatases in humans, other mammals, plants, and a few prokaryotes. The protein fold of tartrate-resistant acid phosphatase (TRAP) resembles that of the catalytic domain of plant purple acid phosphatase and other serine/threonine-protein phosphatases that also contain a metallophosphoesterase domain. One gene produces the various forms which include purple acid phosphatases from spleen and other tissues. Tartrate-resistant acid phosphatase is a biomarker for pathological states in which it is over-expressed. Such conditions include GAUCHER DISEASE; HODGKIN DISEASE; BONE RESORPTION; and NEOPLASM METASTASIS.