Urocortins
Synonyms
Ucn II
Ucn III
Urocortin
Urocortin 1
Urocortin 2
Urocortin 3
Urocortin I
Urocortin II
Urocortin III
Neuropeptides of about 40 amino acids which are structurally similar to CORTICOTROPIN-RELEASING FACTOR. Unlike CRF acting primarily through type 1 CRF RECEPTORS, urocortins signal preferentially through type 2 CRF receptors. Urocortins have wide tissue distribution from fish to mammals, and diverse functions. In mammals, urocortins can suppress food intake, delays gastric emptying, and decreases heat-induced edema.