Wolfram Syndrome

Synonyms

DIDMOAD

DIDMOAD Syndrome

DIDMOADUD

Diabetes Insipidus and Mellitus with Optic Atrophy and Deafness

Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness

Syndrome, Wolfram

Wolfram Syndrome 1

A hereditary condition characterized by multiple symptoms including those of DIABETES INSIPIDUS; DIABETES MELLITUS; OPTIC ATROPHY; and DEAFNESS. This syndrome is also known as DIDMOAD (first letter of each word) and is usually associated with VASOPRESSIN deficiency. It is caused by mutations in gene WFS1 encoding wolframin, a 100-kDa transmembrane protein.