Proto-Oncogene Proteins c-bcr

Synonyms

Breakpoint Cluster Region Protein

Proto Oncogene Protein bcr

Proto Oncogene Protein c bcr

Proto Oncogene Proteins c bcr

Proto-Oncogene Protein bcr

Proto-Oncogene Protein c-bcr

Proto-Oncogene Proteins, bcr

Proto-Oncogene Proteins, c-bcr

bcr Proto Oncogene Proteins

bcr Proto-Oncogene Proteins

c bcr Proteins

c bcr Proto Oncogene Proteins

c-bcr Proteins

c-bcr Proto-Oncogene Proteins

c-bcr, Proto-Oncogene Protein

c-bcr, Proto-Oncogene Proteins

A serine-threonine kinase that contains a C2 DOMAIN and PLECKSTRIN HOMOLOGY DOMAIN. It also has activity as a GTPASE-ACTIVATING PROTEIN for RAC1 PROTEIN and CDC42 PROTEIN. It functions as a negative regulator of CELL PROLIFERATION and NEOPLASTIC CELL TRANSFORMATION and is commonly fused with cellular abl protein to form BCR-ABL FUSION PROTEINS in PHILADELPHIA CHROMOSOME positive LEUKEMIA patients.